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However, another study found that a combination of bitter orange, caffeine, and several other ingredients did not help people lose weight.

Taking a specific combination product (Prograde Metabolism, Prograde Nutrition, Lutz, FL) containing bitter orange, raspberry ketone, caffeine, capsaicin, garlic, ginger, black pepper, cayenne pepper, and chromium along with diet and exercise for 8 weeks also seems to improve weight and energy. John's wort might help for weight reduction when used with a low calorie diet and exercise. Some research suggests that a combination of bitter orange, caffeine, and St. Research on the effects of bitter orange on weight are conflicting. Early research suggests that taking a specific product containing bitter orange along with other ingredients (Zhizhu) three times daily for 4 weeks reduces indigestion. Early research suggests that drinking tea made from the leaves of Indian snakeroot and the fruit of bitter orange for 4 months appears to decrease blood sugar levels in people with diabetes. Insufficient Evidence to Rate Effectiveness for.

Applying bitter orange oil seems to help treat fungal skin infections.

Treating fungal skin infections such as ringworm, athlete's foot, and jock itch.

Uses & Effectiveness Possibly Effective for. SLIDESHOW Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases See Slideshow These chemicals can squeeze blood vessels, increase blood pressure, and cause the heart to beat faster. The concentration and effect of these chemicals can change depending on the part of the plant and the method used for preparation. How does it work?īitter orange has many chemicals that affect the nervous system. There is no evidence to suggest that bitter orange is any safer than ephedra.īitter orange (synephrine) is considered a banned substance by the National Collegiate Athletic Association (NCAA).īefore taking bitter orange, talk with your healthcare professional if you take any medications. Bitter orange and caffeine, a frequent combination in weight loss and bodybuilding products, can cause high blood pressure and increased heart rate in healthy adults with otherwise normal blood pressure. In Asian medicine, the entire dried unripe fruit is used primarily for digestive disorders.īitter orange is frequently used in "ephedra-free" products since the FDA banned ephedra in 2004 for serious side effects on the heart. In manufacturing, bitter orange oil is used in pharmaceuticals, cosmetics, and soaps. The dried peel of the fruit is also used as a seasoning. Because the fruit is so sour and bitter, it is rarely eaten, except in Iran and Mexico. The fruit is used for making marmalades and liqueurs such as Triple Sec, Grand Marnier, Cointreau, and Curacao.

In foods, bitter orange oil is used as a flavoring agent. In aromatherapy, the essential oil of bitter orange is applied to the skin and also inhaled as a painkiller. It is also used for bleeding from the retina, exhaustion accompanying colds, headaches, nerve pain, muscular pain, joint pain, bruises, swelling of the veins (phlebitis), and bed sores. Some people use bitter orange flower and its oil for general feebleness, "tired blood" (anemia), impurities of the skin, hair loss, cancer, frostbite, and as a tonic.īitter orange peel is applied to the skin for swelling (inflammation) of the eyelid and its lining, as well as the retina in the eye. These parts of the bitter orange plant are also used for regulating fat levels in the blood, lowering blood sugar in people with diabetes, stimulating the heart and circulation, "blood purification," disorders of liver and gallbladder, kidney and bladder diseases, and as a sedative for sleep disorders. The bitter orange flower and bitter orange oil are used for gastrointestinal (GI) disorders including ulcers in the intestine, constipation, diarrhea, blood in feces, drooping (prolapsed) anus or rectum, and intestinal gas. Other uses for the fruit and peel are upset stomach, nasal congestion, and chronic fatigue syndrome (CFS). But so far, science has shown only that the oil, when applied to the skin, might be effective for treatment of fungal skin infections (ringworm, jock itch, and athlete's foot).īitter orange peel is also used to improve appetite, and, in surprising contrast, it is also used for weight loss. Bitter orange oil is made from the peel.īitter orange, both taken by mouth and applied to the skin, has many uses. The peel, flower, leaf, fruit, and fruit juice are used to make medicine.